Immunohistochemical evidence that angiotensins I and II are formed by intracellular mechanism in juxtaglomerular cells.
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منابع مشابه
Immunohistochemical evidence that angiotensins I and II are formed by intracellular mechanism in juxtaglomerular cells.
The existence of angiotensin II (AII) immunoreactivity in juxtaglomerular (JG) cells of rat kidney, which has been demonstrated previously by immunohistochemical studies, can be explained either as the product of intracellular synthesis or by the internalization of receptor-bound AII originating in plasma. To resolve these two alternative mechanisms, attempts were made to identify AI in JG cell...
متن کاملExtraction and measurement of circulating angiotensins I and II.
We describe a method for simultaneous extraction of angiotensins I and II from human blood. Blood was diluted with 10 volumes of isotonic saline containing ammonium ethylenediaminetetraacetate, and the angiotensin peptides were extracted by cation-exchange chromatography. The dilution effectively inhibits in vitro production of angiotensin I, conversion of angiotensin I to angiotensin II, and d...
متن کاملJuxtaglomerular cells grown as monolayer cell culture contain renin, angiotensin I-converting enzyme, and angiotensin I and II/III.
A monolayer cell culture of juxtaglomerular cells (JGC) was derived from the renal cortex of neonatal rats. The JGC had the characteristics of those within the kidney, including peripheral dense bodies and myofibrils indicating a smooth muscle origin; rough ER containing fluffy material consistent with protein synthesis; a prominent Golgi apparatus for packaging granules, and granules having th...
متن کاملAngiotensin II induces oscillations of intracellular calcium and blocks anomalous inward rectifying potassium current in mouse renal juxtaglomerular cells.
Simultaneous patch-clamp and fura-2 measurements were used to investigate the electrical properties and receptor-mediated changes of intracellular calcium in renal juxtaglomerular cells. Here we report the presence of voltage-activated inward and outward rectifying potassium currents and the inhibition of the anomalous inward rectifying potassium current by angiotensin II (ANG-II). This action ...
متن کاملJuxtaglomerular cells.
• Because juxtaglomerular (JG) cells are sprinkled throughout the renal cortex, just as beta cells are sprinkled throughout the exocrine pancreas, the classical extirpation and substitution approach in endocrinology is a limited means for the study of their function. Until they can be isolated and pure extracts made, or until an "alloxan" for JG cells is discovered, their study will depend chie...
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ژورنال
عنوان ژورنال: Hypertension
سال: 1982
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.4.3_pt_2.70